Parkinson’s disease (PD)
belongs to a group of neurodegenerative conditions called motor system diseases,
which are the result of the loss of dopaminergic brain cells. The primary
symptoms of PD are postural instability, or impaired balance and coordination, tremor,
or trembling in limbs, jaw, and face rigidity, or stiffness of the limbs and
slowness of trunk movement, 1.
The rampancy of the
disease ranges from 41 people per 100,000 in the fourth decade of life to more
than 1,900 people per 100,000 among those 80 and older 2.
Patients are usually prescribed
Levodopa, COMT Inhibitors, Dopamine Agonists, Non-Dopaminergic Therapy, etc
3. Therefore, assessing of prescriptions associated to the disease is necessary
to improve the therapeutic efficacy and to reduce the side effects & to
provide feedback to the prescribers. The main aim of this drug utilization
study is to facilitate rational drug usage and knowing the efficacy of each one
of them 4.
Quality of Life (QoL) is
a multi-dimensional construct, which consists of at least three main domains:
physical, mental and social. In medicinal sciences, health-related quality of
life concept is often used by researchers and scientists. It focuses on the
impact of the disease and treatment as well as on patients’ perception of their
lifestyle and on subjective well-being or satisfaction with life 5.
Therefore, analysis of
the severity of any disease should include not only the clinical factors but
also the psychological & social factors concern the patient. Parkinson’s
Disease has a profound negative impact on the Quality of Life (QoL) as pointed
out by numerous studies, patients suffer from weakness, dementia, emotional
problems, sleep disorders, difficulty in speech and balance, depression,
diminished cognitive functions and several other lifestyle changes 6.
For analysis of QoL,
some questionnaires were prepared exclusively
for patients suffering from Parkinson’s disease (PD). The two well-known
scales are Parkinson’s Disease Questionnaire (PDQ-39) and Parkinson` s Disease
Quality of Life Questionnaire (PDQL). Martinez-Martin reported that the quality
of life scales are useful in evaluating the results of rehabilitation and drug
treatment of Parkinson’s disease or neurosurgery 7.
Hence, Parkinson’s Disease Questionnaire- 39 is being used in this study.